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维生素 C 可提高体细胞核重编程的质量。

Vitamin C improves the quality of somatic cell reprogramming.

机构信息

Stem Cell and Cancer Biology Group at the Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

出版信息

Nat Genet. 2012 Mar 28;44(4):366-7. doi: 10.1038/ng.2222.

DOI:10.1038/ng.2222
PMID:22456737
Abstract

The reprogramming of somatic cells to a pluripotent state is prone to errors that could hamper the use of this technology. A new study now shows that vitamin C enhances the quality of somatic cell reprogramming in mice, highlighting the possibility that further manipulation of culture conditions could improve this technology for regenerative medicine.

摘要

体细胞重编程为多能状态容易出错，这可能会阻碍这项技术的应用。一项新的研究表明，维生素 C 可提高小鼠体细胞重编程的质量，这突出表明进一步对培养条件进行操作可能会提高这项再生医学技术。

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Nat Genet. 2012 Mar 4;44(4):398-405, S1-2. doi: 10.1038/ng.1110.
2
The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner.组蛋白去甲基酶 Jhdm1a/1b 以依赖维生素 C 的方式增强体细胞核重编程。
Cell Stem Cell. 2011 Dec 2;9(6):575-87. doi: 10.1016/j.stem.2011.10.005. Epub 2011 Nov 17.
3
Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming.
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RSC Adv. 2021 Dec 8;11(62):39306-39310. doi: 10.1039/d1ra07702c. eCollection 2021 Dec 6.
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Metabolic-Epigenetic Axis in Pluripotent State Transitions.多能状态转变中的代谢-表观遗传轴
Epigenomes. 2019 Jul 31;3(3):13. doi: 10.3390/epigenomes3030013.
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Cells. 2021 Nov 25;10(12):3310. doi: 10.3390/cells10123310.
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