Roy Somak, Hooda Shveta, Huang George J, Pantanowitz Liron, Parwani Anil V
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Int J Surg Pathol. 2012 Oct;20(5):531-5. doi: 10.1177/1066896912438588. Epub 2012 Mar 27.
Renal cell carcinoma of chromophobe type is a malignant neoplasm with characteristic large cells that exhibit prominent cell membranes. Primary renal carcinoid tumors are rare tumors with the histological appearance similar to well-differentiated neuroendocrine tumors at other sites. Chromophobe renal cell carcinoma with neuroendocrine differentiation is exceedingly rare. The authors describe a case of a chromophobe renal cell carcinoma and carcinoid tumor of the kidney presenting as distinct masses in the same kidney in a 34-year-old male. The histologic and immunohistochemical features of both the tumors were characteristic with no overlapping features. The carcinoid tumor presented at a higher stage with nodal metastasis. To the best of the authors' knowledge, this is the first case of 2 morphologically distinct tumors, one chromophobe renal cell carcinoma and the other primary carcinoid tumor in the same kidney.
嫌色细胞型肾细胞癌是一种恶性肿瘤，其特征性大细胞具有突出的细胞膜。原发性肾类癌肿瘤罕见，其组织学表现与其他部位分化良好的神经内分泌肿瘤相似。具有神经内分泌分化的嫌色细胞肾细胞癌极为罕见。作者描述了一例34岁男性患者，其嫌色细胞肾细胞癌和肾类癌肿瘤在同一肾脏中表现为不同的肿块。两种肿瘤的组织学和免疫组化特征均具有特异性，无重叠特征。类癌肿瘤分期较高，伴有淋巴结转移。据作者所知，这是首例同一肾脏中出现两种形态学上不同肿瘤的病例，一种是嫌色细胞肾细胞癌，另一种是原发性类癌肿瘤。
