Nirale N M, Nagarsenker M S, Mendon S B, Chanagare R, Katkurwar A, Lugade V
Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai-400 098, India.
Indian J Pharm Sci. 2011 May;73(3):282-6. doi: 10.4103/0250-474X.93514.
The aerodynamic diameter of pharmaceutical aerosols is the main factor governing their deposition in the human respiratory tract. Particle size of the pharmaceutical aerosols is characterized by liquid impingers and Andersen Cascade Impactors. The present study was aimed at comparing two metered dose inhaler formulation containing formoterol fumarate (6 μg) and budesonide (200 μg). These two formulations were evaluated by using Twin Stage Impinger and Andersen Cascade Impactor. Study revealed that developed metered dose inhaler I formulation of the formoterol fumarate and budesonide had lower mass median aerodynamic diameter and higher fine particle fraction than marketed formulation.
药用气雾剂的空气动力学直径是决定其在人体呼吸道中沉积的主要因素。药用气雾剂的粒径通过液体冲击器和安德森级联冲击器来表征。本研究旨在比较两种含有富马酸福莫特罗（6μg）和布地奈德（200μg）的定量吸入气雾剂配方。使用双级冲击器和安德森级联冲击器对这两种配方进行了评估。研究表明，所研发的富马酸福莫特罗和布地奈德定量吸入气雾剂I配方的质量中值空气动力学直径较低，细颗粒分数高于市售配方。
