Ogbe P J, Idoko O A, Ezimah A C U, Digban K A, Oguntayo Beatris Olatundun
Fatima College of Medicine, Valenzula City, Philippines.
Clin Lab Sci. 2012 Winter;25(1):7-12.
In HIV-infected populations from developing countries, it is unclear what proportion of anemia is attributable to iron deficiency (ID). The objective of this study was to evaluate the iron status in anemia of chronic disease of patients with Human Immunodeficiency Virus (HIV) infection attending Federal Medical Centre, Makurdi.
A total of 312 subjects comprising of 207 confirmed HIV positive patients and 105 apparently healthy subjects as control were evaluated for indices of anemia using SYSMEX KX 21N hematology analyzer machine (Kobe, Japan), CD4 count using CYFLOW SL machine (Artec, Germany), and total iron binding capacity and serum iron using colorimetric method.
While results showed that Serum Iron, Transferrin Saturation, PCV, RBC, MCV, MCH, MCHC and RDWCV are within normal reference range but statistically different (p < 0.05) compared to the controls. Stratifying them on the basis of CD4 count showed that in AIDS patients the indicators are generally lower with Hb, PCV, MCH and RDWCV showing statistical significance (p < 0.05) compared with patients with CD4 > 200 cells/mm3. Serum iron (50%) and transferring saturation (47.9%) contributed highest to anemia prevalence especially in males while Hb concentration (47.2%) is the major contributor to anemia in females.
It was concluded therefore that albeit, on average, the parameters of iron status did not indicate iron deficiency or iron overload in the HIV-status groups and AIDS patients, a large percentage of patients did have anemia of chronic disease with HIV-infected women afflicted more often. The anemia is generally normocytic hypochromic in AIDS patients.
在发展中国家的艾滋病毒感染人群中，尚不清楚贫血有多大比例归因于缺铁（ID）。本研究的目的是评估在马库尔迪联邦医疗中心就诊的人类免疫缺陷病毒（HIV）感染患者的慢性病贫血中的铁状态。
使用SYSMEX KX 21N血液分析仪（日本神户）评估了总共312名受试者，其中包括207名确诊的HIV阳性患者和105名明显健康的受试者作为对照，以检测贫血指标；使用CYFLOW SL机器（德国Artec）检测CD4计数；使用比色法检测总铁结合力和血清铁。
结果显示，血清铁、转铁蛋白饱和度、红细胞压积、红细胞计数、平均红细胞体积、平均红细胞血红蛋白含量、平均红细胞血红蛋白浓度和红细胞体积分布宽度变异系数均在正常参考范围内，但与对照组相比有统计学差异（p<0.05）。根据CD4计数对他们进行分层显示，在艾滋病患者中，这些指标通常较低，与CD4>200细胞/mm3的患者相比，血红蛋白、红细胞压积、平均红细胞血红蛋白含量和红细胞体积分布宽度变异系数具有统计学意义（p<0.05）。血清铁（50%）和转铁蛋白饱和度（47.9%）对贫血患病率的贡献最高，尤其是在男性中，而血红蛋白浓度（47.2%）是女性贫血的主要原因。
因此得出结论，尽管平均而言，铁状态参数在HIV感染组和艾滋病患者中未表明缺铁或铁过载，但很大比例的患者确实患有慢性病贫血，HIV感染女性受影响更频繁。艾滋病患者的贫血通常为正细胞低色素性贫血。
