Elias D, Bone A J, Baird J D, Cooke A, Cohen I R
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Diabetes. 1990 Dec;39(12):1467-71. doi: 10.2337/diab.39.12.1467.
BB/E rats spontaneously develop a form of autoimmune diabetes resembling insulin-dependent diabetes mellitus (IDDM) in humans. IDDM results from central destruction of the insulin-producing beta-cells of the pancreatic islets. Herein, we report that the outbreak of IDDM in BB/E rats is preceded by the spontaneous development of an anti-idiotypic antibody to a particular antibody to insulin made by the rats. This anti-idiotype, designated anti-DM-id, behaves as an antibody to the insulin-hormone receptor. Thus, a spontaneous anti-idiotypic antibody network whose products can affect the peripheral utilization of insulin seems to accompany the central destruction of beta-cells in developing IDDM.
BB/E大鼠会自发患上一种自身免疫性糖尿病，类似于人类的胰岛素依赖型糖尿病（IDDM）。IDDM是由胰岛中产生胰岛素的β细胞的中枢性破坏引起的。在此，我们报告，在BB/E大鼠中IDDM的爆发之前，会自发产生一种针对大鼠产生的特定胰岛素抗体的抗独特型抗体。这种抗独特型抗体，命名为抗-DM-id，表现为胰岛素-激素受体的抗体。因此，一个其产物可影响胰岛素外周利用的自发抗独特型抗体网络似乎伴随着IDDM发展过程中β细胞的中枢性破坏。
