Oral Cancer Research Team, Cancer Research Initiatives Foundation (CARIF), 2nd Floor Outpatient Centre, Sime Darby Medical Centre, Selangor, Malaysia.
Cancer Lett. 2012 Aug 1;321(1):18-26. doi: 10.1016/j.canlet.2012.03.025. Epub 2012 Mar 27.
MAGE proteins have been shown to be good targets for cancer immunotherapy. We demonstrate that MAGED4B is over-expressed in more than 50% of Oral Squamous Cell Carcinoma (OSCC) tissues and the expression of MAGED4B is associated with lymph node metastasis and poor disease specific survival. OSCC cell lines that over-express MAGED4B promote migration in vitro, exhibit an increase in cell growth both in vitro and in vivo, and are more resistant to apoptosis compared to control cells. Our data suggest that MAGED4B over-expression is a driver in oral carcinogenesis and argues strongly that this protein may represent a potential therapeutic target in OSCC.
MAGE 蛋白已被证明是癌症免疫治疗的良好靶点。我们证明，MAGED4B 在超过 50%的口腔鳞状细胞癌（OSCC）组织中过表达，并且 MAGED4B 的表达与淋巴结转移和不良疾病特异性生存相关。过表达 MAGED4B 的 OSCC 细胞系在体外促进迁移，在体外和体内均表现出细胞生长增加，并且对细胞凋亡的抵抗力比对照细胞更强。我们的数据表明，MAGED4B 的过表达是口腔癌发生的驱动因素，并强烈表明该蛋白可能是 OSCC 的潜在治疗靶点。
