Department of Medicine, Queen Mary Hospital, Hong Kong.
J Stroke Cerebrovasc Dis. 2012 Nov;21(8):915.e11-5. doi: 10.1016/j.jstrokecerebrovasdis.2012.02.004. Epub 2012 Mar 28.
Cerebral venous thrombosis is an uncommon condition with difficulties in diagnosis and treatment. There is limited study on the best treatment option for this disease. The mainstay of treatment remains systemic anticoagulation with a lengthy duration of warfarin, which has a troublesome unpredictable drug effect, various drug and food interactions, and an increased risk of bleeding. Recent availability of direct thrombin inhibitor provides an alternative option of systemic anticoagulation in various thromboembolism conditions. We report 2 cases of cerebral venous thrombosis treated with a direct thrombin inhibitor with good clinical and radiologic results.
脑静脉血栓形成是一种少见病症，其诊断和治疗均存在困难。目前对于这种疾病的最佳治疗方案研究有限。治疗的主要方法仍然是全身性抗凝治疗，使用华法林的时间较长，其药物作用不可预测，存在各种药物和食物相互作用，出血风险增加。最近直接凝血酶抑制剂的出现为各种血栓栓塞疾病的全身性抗凝治疗提供了另一种选择。我们报告了 2 例使用直接凝血酶抑制剂治疗脑静脉血栓形成的病例，取得了良好的临床和影像学结果。
