Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
J Leukoc Biol. 2012 Jul;92(1):59-65. doi: 10.1189/jlb.1011529. Epub 2012 Mar 29.
The lung is one of the most immunologically challenged organs and can be affected by a number of pathogens, including bacteria, virus, fungi, and parasites. The development and chronicity of pulmonary infection are determined by the early innate response to the pathogenic stimuli and are regulated at multiple levels. Initial studies have indicated that the interaction of Notch and Notch ligands plays a critical role during development, and further, the Notch system is an important bridge between APCs and T cell communication circuits. APCs are essential regulators of the innate immune response. They can respond to PAMPs through PRRs, which function in the recognition of pathogenic components and play an important role in the innate and adaptive immune response. T cells are essential regulators of adaptive immune responses and infectious diseases. However, the role of the Notch system in the cross-talk between APC and T cells during pulmonary infection is still poorly understood. In the present review, we discuss recent findings that explore the mechanisms underlying the role of Notch signaling in the linkage of innate and adaptive immunity, including pulmonary infection though PPRs and Notch activation.
肺是最具免疫挑战性的器官之一，可受到多种病原体的影响，包括细菌、病毒、真菌和寄生虫。肺部感染的发生和慢性化取决于对致病刺激的早期固有反应，并在多个层面受到调节。最初的研究表明，Notch 和 Notch 配体的相互作用在发育过程中起着关键作用，此外，Notch 系统是 APC 和 T 细胞通讯回路之间的重要桥梁。APC 是固有免疫反应的重要调节剂。它们可以通过 PRRs 对 PAMPs 做出反应，PRRs 可识别病原体成分，在固有和适应性免疫反应中发挥重要作用。T 细胞是适应性免疫反应和传染病的重要调节剂。然而， Notch 系统在肺部感染期间 APC 和 T 细胞之间的串扰中的作用仍知之甚少。在本综述中，我们讨论了最近的发现，这些发现探讨了 Notch 信号在固有和适应性免疫联系中的作用的机制，包括通过 PPRs 和 Notch 激活进行肺部感染。
