AP-HP, Hôpital Antoine Béclère, Département d'Anesthésie-Réanimation & Université Paris-Sud, Clamart, France.
Curr Opin Anaesthesiol. 2012 Jun;25(3):286-91. doi: 10.1097/ACO.0b013e3283530dab.
To guide the optimal fluid management during cesarean delivery. The article focuses on fluid management to prevent hypotension during cesarean delivery performed under spinal anesthesia and excludes obstetric hemorrhage.
The literature underlines that crystalloid preloading is ineffective or poorly effective to prevent spinal hypotension during cesarean delivery. Crystalloid coloading is better but the effectiveness reported is variable and may depend on the volume used and the speed of administration at onset of sympathetic blockade. Hydroxyethyl starch (HES) preloading is more consistently effective in reducing the incidence and severity of hypotension. HES coloading appears as effective as HES preloading. Because none of these fluid-loading methods is completely effective at preventing hypotension, some sort of prophylactic vasopressor regimen should always be added. Routine fluid loading is no longer advocated prior to spinal anesthesia for cesarean delivery in preeclampsia and should be used with caution in women with multiple gestations.
Current evidence suggests that combining a prophylactic vasopressor regimen with HES preloading, HES coloading or crystalloid coloading is the best method of preventing maternal hypotension after the initiation of spinal anesthesia. Crystalloid preloading is clinically ineffective and thus should no longer be used.
指导剖宫产术中的最佳液体管理。本文重点关注预防脊髓麻醉下剖宫产术中低血压的液体管理,不包括产科出血。
文献强调,晶体预负荷对预防剖宫产术中脊髓低血压无效或效果较差。晶体负荷更好,但报道的效果是可变的,可能取决于使用的体积和在交感神经阻滞开始时的给药速度。羟乙基淀粉(HES)预负荷更一致地有效降低低血压的发生率和严重程度。HES 负荷与 HES 预负荷一样有效。由于这些液体负荷方法都不能完全有效预防低血压,因此应始终添加某种预防性血管加压药方案。在子痫前期的脊髓麻醉前不再提倡常规液体负荷,在多胎妊娠的妇女中应谨慎使用。
目前的证据表明,将预防性血管加压药方案与 HES 预负荷、HES 负荷或晶体负荷相结合是预防脊髓麻醉后产妇低血压的最佳方法。晶体预负荷在临床上无效,因此不应再使用。