Prostaglandin E2 and F2 alpha levels in human dental cyst fluid as bone resorbing factors?

Prostaglandin E2 and F2 alpha concentrations in aspirated cyst fluid of 14 human dental cysts were measured by radioimmunoassay. The mean concentrations were found to be 22.0 ng PGE2/g cyst fluid and 4.0 ng PGF2 alpha/g cyst fluid. As compared to plasma conditions a remarkable shift of the ratio of the two prostaglandins to PGE2 could be demonstrated. Due to the high concentrations of PGE2 found in the cyst material it is suggested that this prostaglandin may be one of the bone resorbing factors to be responsible for the destruction of bone in periodontal diseases.