头低位倾斜时黄斑中心凹下脉络膜厚度和黄斑中心凹视网膜厚度

Subfoveal choroidal thickness and foveal retinal thickness during head-down tilt.

作者信息

Shinojima Ari, Iwasaki Ken-Ichi, Aoki Ken, Ogawa Yojiro, Yanagida Ryo, Yuzawa Mitsuko

机构信息

Division of Ophthalmology, Department of Visual Science, Nihon University School of Medicine, Tokyo, Japan.

出版信息

Aviat Space Environ Med. 2012 Apr;83(4):388-93. doi: 10.3357/asem.3191.2012.

DOI:10.3357/asem.3191.2012

PMID:22462366

Abstract

INTRODUCTION

To reveal subtle morphological changes in the eye during simulated microgravity for spaceflights, we measured subfoveal choroidal thickness and foveal retinal thickness during 10 degrees head-down tilt (HDT). We hypothesized that elevated ophthalmic vein pressure during simulated microgravity increases subfoveal choroidal thickness via enlargement of the choroidal vasculature and greater choroidal blood volume.

METHODS

The right eyes of nine healthy subjects (seven men, two women) were examined. Subfoveal choroidal thickness and foveal retinal thickness were measured using spectral domain-optical coherence tomography in the sitting position, and after 15 and 30 min of 10 degrees HDT. Intraocular pressure was also measured.

RESULTS

Mean subfoveal choroidal thickness (+/- SEM) increased from 300 +/- 31 microm in the sitting position to 315 +/- 31 microm with 15-min HDT, and 333 +/- 31 microm with 30-min HDT. However, no change in foveal retinal thickness was observed (228 +/- 9 microm in the sitting position, 228 +/- 10 microm with 15-min HDT and 228 +/- 9 microm with 30-min HDT). Intraocular pressure increased from 14 +/- 1 mmHg in the sitting position to 21 +/- 2 mmHg with 30-min HDT (54 +/- 6%, N = 5).

DISCUSSION

Subfoveal choroidal thickness and intraocular pressure were increased by HDT during simulated microgravity, although no change in foveal retinal thickness was observed.

摘要

引言

为揭示太空飞行模拟微重力环境下眼睛的细微形态变化，我们测量了10度头低位倾斜（HDT）期间黄斑中心凹下脉络膜厚度和黄斑视网膜厚度。我们假设，模拟微重力环境下眼静脉压力升高会通过脉络膜血管扩张和脉络膜血容量增加，导致黄斑中心凹下脉络膜厚度增加。

方法

对9名健康受试者（7名男性，2名女性）的右眼进行检查。采用光谱域光学相干断层扫描技术，在坐位、10度HDT 15分钟和30分钟后，测量黄斑中心凹下脉络膜厚度和黄斑视网膜厚度。同时测量眼压。

结果

黄斑中心凹下脉络膜平均厚度（±标准误）从坐位时的300±31微米增加到HDT 15分钟时的315±31微米，以及HDT 30分钟时的333±31微米。然而，黄斑视网膜厚度未见变化（坐位时为228±9微米，HDT 15分钟时为228±10微米，HDT 30分钟时为228±9微米）。眼压从坐位时的14±1毫米汞柱增加到HDT 30分钟时的21±2毫米汞柱（增加54±6%，N = 5）。