Instituto Nacional de Silicosis, Hospital Universitario Central de Asturias, Facultad de Medicina, Universidad de Oviedo, España.
Arch Bronconeumol. 2012 Jul;48(7):240-6. doi: 10.1016/j.arbres.2012.02.003. Epub 2012 Mar 30.
Inhaled medication is the first-line treatment of diseases such as asthma or chronic obstructive pulmonary disease. Its effectiveness is related to the amount of drug deposited beyond the oropharyngeal region, the place where the deposit occurs and its distribution (uniform or not). It is also important to consider the size of the inhaled particles, the breathing conditions, the geometry of the airways and the mucociliary clearance mechanisms. Currently, mathematical models are being applied to describe the deposition of inhaled drugs based on the size of the particles, the inspiratory flow and the anatomical distribution of the bronchial tree. The deposition of particles in the small airways gets maximum attention from pharmaceutical companies and is of great interest as it is related with a better control in patients receiving these drugs.
吸入式药物是治疗哮喘或慢性阻塞性肺疾病等疾病的首选方法。其疗效与药物在口咽区域以外的沉积量、沉积部位及其分布（均匀或不均匀）有关。吸入颗粒的大小、呼吸条件、气道几何形状和黏液纤毛清除机制也很重要。目前，正在应用数学模型根据颗粒大小、吸气流量和支气管树的解剖分布来描述吸入药物的沉积。小气道中的颗粒沉积受到制药公司的最大关注，因为它与接受这些药物的患者更好的控制有关，所以非常有意义。
