Arnott Andrew, Watson Malcolm, Sim Malcolm
Queen Elizabeth University Hospital, Glasgow, UK.
J Intensive Care Soc. 2024 Feb;25(1):78-88. doi: 10.1177/17511437231199899. Epub 2023 Sep 20.
Nebulisers are devices that reduce a body of liquid into a fine aerosol suitable for inhalation. Utilising the efficiency of pulmonary drug absorption, they offer a safe and powerful modality for local and systemic drug delivery in the treatment of critical illness. In comparison to conventional jet (JN) and ultrasonic nebulisers (USN), the advent of vibrating mesh nebulisers (VMN) has significantly improved the therapeutic potential of modern devices. This review article aims to summarise the history and evolution of nebulisers from first inception through to the modern vibrating mesh technology. It provides an overview on the basic science of nebulisation and pulmonary drug delivery, and the current use of nebulised therapies in critical care.
雾化器是一种将液体转化为适合吸入的细气雾剂的装置。利用肺部药物吸收的效率，它们为危重病治疗中的局部和全身药物递送提供了一种安全且有效的方式。与传统喷射式（JN）和超声雾化器（USN）相比，振动网孔雾化器（VMN）的出现显著提高了现代设备的治疗潜力。这篇综述文章旨在总结雾化器从最初发明到现代振动网孔技术的历史和演变。它概述了雾化和肺部药物递送的基础科学，以及雾化疗法在重症监护中的当前应用。
