UMR 190-Emerging viral pathologies (IRD/Université Aix-Marseille II), Institut de Recherche pour Développement, France.
Infect Genet Evol. 2012 Jul;12(5):905-12. doi: 10.1016/j.meegid.2012.03.006. Epub 2012 Mar 20.
Historical sources abound in references to outbreaks of a disease resembling dengue fever. Medical observers reported on its rapid onset and great expansion in the population, the diversity and changeability of its clinical features and its overall mildness. In 1874, an epidemic disease with fever, rash and rheumatic pains as main symptoms broke out in the Portuguese colony of Macau, South China. It was similar to the epidemic disease which swept the colony 2 years before during the socalled dengue pandemic of 1870-1873. The 1874 epidemic disease was variously labeled by local physicians, including dengue fever. In his report on the disease, Dr. Lúcio Augusto da Silva, hence at the head of the health services of Macau, discussed on the nature of the epidemic febrile disease. Here, I review the data on the 1874 epidemic outbreak and put them in the context of historical dengue-like outbreaks. A possible Chikungunya etiology of the disease is postulated.
历史资料中充斥着类似于登革热的疾病爆发的记载。医学观察家报告称，该病发病迅速，在人群中迅速蔓延，其临床特征多样且多变，整体较为温和。1874 年，中国南部的葡萄牙殖民地澳门爆发了一种以发热、皮疹和风湿痛为主要症状的传染病。该病与 2 年前席卷该殖民地的所谓 1870-1873 年登革热大流行期间爆发的传染病相似。当地医生对这种传染病有多种称呼，包括登革热。在他对该病的报告中，澳门卫生部门负责人卢西奥·奥古斯托·达席尔瓦医生讨论了这种流行发热疾病的性质。在这里，我回顾了 1874 年疫情爆发的数据，并将其置于历史上类似登革热疫情的背景下。该疾病的病因可能是基孔肯雅热。
