University of Colorado Denver, Aurora, CO 80045, USA.
J Clin Virol. 2012 Jul;54(3):276-8. doi: 10.1016/j.jcv.2012.02.026. Epub 2012 Mar 31.
Human herpes simplex virus infections are very common and represent significant morbidity in the immunocompromised host. Patients with acyclovir resistant strains of HSV based on viral thymidine kinase gene mutations need alternative therapeutic approaches. Leflunomide has been shown to possess antiviral activity against several viruses. Herein we describe a case of acyclovir resistant HSV-2 proctitis in an HIV patient successfully treated with leflunomide without significant side effects.
人类单纯疱疹病毒感染非常普遍，在免疫功能低下的宿主中表现出较高的发病率。基于病毒胸苷激酶基因突变的阿昔洛韦耐药型单纯疱疹病毒感染者需要替代治疗方法。来氟米特已被证明对多种病毒具有抗病毒活性。本文描述了一例 HIV 感染者的阿昔洛韦耐药型单纯疱疹病毒 2 型直肠炎，使用来氟米特治疗取得成功，且无明显副作用。
