Division of Infectious Diseases, Vanderbilt University Medical Center, A2200 MCN 1161 21st Avenue South Nashville, Nashville, TN, 37232-2605, USA.
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Infection. 2017 Oct;45(5):705-707. doi: 10.1007/s15010-017-1027-y. Epub 2017 May 15.
Recurrent anogenital herpes simplex virus infections are common in patients with human immunodeficiency virus (HIV), of whom approximately 5% develop resistance to acyclovir. We present a case of a 49-year-old man with HIV who had an 8-year history of recurrent left inguinal herpes simplex virus type 2 ulcerations. He initially responded to oral acyclovir, but developed resistance to acyclovir and eventually foscarnet. The lesion progressed to a large hypertrophic mass that required surgical excision, which led to resolution without recurrences. Our case highlights the importance of surgical excision as a treatment option in refractory herpes simplex virus anogenital infections.
复发性生殖器单纯疱疹病毒感染在人类免疫缺陷病毒（HIV）患者中很常见，其中约 5%的患者对阿昔洛韦产生耐药性。我们报告了 1 例 49 岁 HIV 患者，他患有 8 年的左侧腹股沟生殖器疱疹病毒 2 型复发性溃疡。他最初对口服阿昔洛韦有反应，但对阿昔洛韦产生耐药性，最终对膦甲酸钠耐药。病变进展为一个大的肥大性肿块，需要手术切除，切除后病变得到解决且无复发。我们的病例强调了手术切除作为难治性生殖器单纯疱疹病毒感染的一种治疗选择的重要性。
