Department of Internal Medicine, Tor Vergata University, Rome, Italy.
Nephrol Dial Transplant. 2012 Apr;27(4):1689-90. doi: 10.1093/ndt/gfs044.
Haemodialysis patients show sympathetic hyperactivity. Hyperactivation of the sympathetic nervous system aggravates hypertension and it is related to left ventricular hypertrophy, heart failure, arrhythmias and atherogenesis. We report the first use of renal sympathetic nerve ablation for correction of uncontrolled hypertension in an end-stage renal disease patient on maintenance dialysis. We observed a progressive and sustained reduction of systemic blood pressure. Our case demonstrates the safety, the feasibility and the efficacy of this procedure. These findings suggest, however, that further clinical trials are needed into renal nerve radiofrequency ablation therapy for the treatment of hypertension and for the improvement of cardiovascular prognosis in this high-risk patient group.
血液透析患者表现出交感神经活性亢进。交感神经系统的过度激活会加重高血压，并与左心室肥厚、心力衰竭、心律失常和动脉粥样硬化形成有关。我们报告了首例使用肾交感神经消融术纠正维持性透析的终末期肾病患者的未控制高血压。我们观察到全身血压逐渐持续降低。我们的病例证明了该手术的安全性、可行性和疗效。然而，这些发现表明，需要进一步进行临床试验，以评估射频消融肾神经治疗高血压的效果，并改善这一高危患者群体的心血管预后。
