Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, 11000, Serbia.
Faculty of Medicine, Institute of Pathophysiology "Ljubodrag Buba Mihailović", University of Belgrade, Belgrade, 11000, Serbia.
Curr Med Chem. 2024;31(29):4602-4620. doi: 10.2174/0109298673274823231220063652.
Arterial hypertension (AH) is recognized as the most common illness within the group of cardiovascular diseases and the most massive chronic non-infectious disease in the world. The number of hypertensive patients worldwide has reached 1.28 billion, contributing to an increase in cardiovascular diseases and premature death globally. The high prevalence of hypertension emphasizes the importance of effectively treating this condition. Elevated blood pressure often leads to lethal complications (heart failure, stroke, renal disorders, etc.) if left untreated. Considering an increase in AH prevalence in the future, a successful therapeutical approach to this disease and its complications is essential. The goal of AH treatment is to maintain normotensive blood pressure through various approaches, including lifestyle changes, a well-balanced diet, increased physical activity, psychoeducation, and, when necessary, pharmacotherapy. The evolving pharmacotherapeutic landscape reflects the progress made in our understanding of hypertension and emphasizes the need for continuous innovation to meet the challenges posed by this prevalent global health concern. The journey toward more effective and tailored treatments for hypertension is ongoing, and the introduction of new medications plays a pivotal role in shaping the future of antihypertensive pharmacotherapy.
高血压（AH）被认为是心血管疾病中最常见的疾病，也是世界上最普遍的慢性非传染性疾病。全球高血压患者已达 12.8 亿，导致心血管疾病和全球过早死亡的人数增加。高血压的高患病率强调了有效治疗这种疾病的重要性。如果不进行治疗，血压升高常常会导致致命的并发症（心力衰竭、中风、肾脏疾病等）。考虑到未来 AH 患病率的增加，成功治疗这种疾病及其并发症至关重要。AH 治疗的目标是通过各种方法维持正常血压，包括生活方式改变、均衡饮食、增加身体活动、心理教育以及在必要时进行药物治疗。不断发展的药物治疗领域反映了我们对高血压的理解取得的进展，并强调需要不断创新，以应对这一普遍存在的全球健康问题带来的挑战。朝着更有效和个性化的高血压治疗方法前进的道路仍在继续，引入新的药物在塑造抗高血压药物治疗的未来方面发挥着关键作用。
