Srivastava Neena, Prakash Jai, Lakhan Ram, Agarwal C G, Pant D C, Mittal Balraj
Indian J Clin Biochem. 2011 Apr;26(2):125-30. doi: 10.1007/s12291-010-0099-6. Epub 2011 Jan 13.
Glucocorticoids and its receptor are known to be involved in the dysregulation of hormone and lipid levels. Therefore, we evaluated the association of Bcl1 gene polymorphism of glucocorticoids receptor (GCR) gene variant with hormone and lipid levels in Northern Indians obese. A total of 435 obese and non-obese age matched subjects were included in the case-control study. Lipid and hormonal levels were estimated using standard protocols. Analysis of +646 C>G NR3C1 gene polymorphism was done using PCR-RFLP. The frequencies of GR Bcl1, C>G genotypes and alleles did not differ significantly (P > 0.05) between obese and non-obese. The +646 G allele carriers had higher waist to hip ratio, blood pressure, insulin and glucose levels than non-carriers in obese subjects while diastolic blood pressure and glucose in non-obese. The NR3C1, +646 C>G polymorphism did not associate with obesity. However, the GG genotype may modulate blood pressure, blood glucose and hormonal levels in northern Indians.
已知糖皮质激素及其受体与激素和脂质水平的失调有关。因此，我们评估了糖皮质激素受体（GCR）基因变体的Bcl1基因多态性与印度北部肥胖人群激素和脂质水平之间的关联。共有435名年龄匹配的肥胖和非肥胖受试者纳入了病例对照研究。使用标准方案评估脂质和激素水平。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法分析+646 C>G NR3C1基因多态性。肥胖组和非肥胖组之间GR Bcl1、C>G基因型和等位基因频率无显著差异（P>0.05）。在肥胖受试者中，+646 G等位基因携带者的腰臀比、血压、胰岛素和血糖水平高于非携带者，在非肥胖受试者中，舒张压和血糖水平较高。NR3C1基因+646 C>G多态性与肥胖无关。然而，GG基因型可能会调节印度北部人群的血压、血糖和激素水平。
