Ekaidem Itemobong S, Bolarin Debayo M, Udoh Alphonsus E, Etuk Saturday J, Udiong Christopher E J
Indian J Clin Biochem. 2011 Apr;26(2):187-92. doi: 10.1007/s12291-011-0127-1. Epub 2011 Apr 7.
Plasma fibronectin (FN) levels in obese/overweight and non-obese pregnant women were evaluated as a possible risk factor for preeclampsia. A total of one hundred and sixty three pregnant women attending antenatal clinic at University of Calabar Teaching Hospital participated in the study and sixty non-pregnant women served as control. About 77 (47.24%) of the pregnant women were followed up for any subsequent development of preeclampsia during the pregnancy. Fibronectin levels in plasma were measured by ELISA assay and serum total protein, urea and creatinine were determined spectrophotometrically. The mean plasma FN concentration of non-obese pregnant women in first trimester was lower than those of the non-pregnant women by 24%, but however, increased to the non-pregnant level in second and third trimesters. Obese/overweight pregnant women had significantly (P < 0.05) higher values than non-obese pregnant women in second and third trimesters. FN in obese/overweight pregnant women correlated positively with mean arterial blood pressure (MAP: r = 0.414, P = 0.04). About 28.57% of the pregnant women with FN above cut off point of 330 μg/ml at 18-24 weeks of gestation developed preeclampsia. This value increased to 40.0% when only the obese/overweight women were considered. On analysis of both fibronectin >330 μg/ml and MAP > 90, the predictive value increased to 66.7%. We therefore conclude that elevated FN may be regarded as a risk factor of preeclampsia especially among the obese women.
对肥胖/超重和非肥胖孕妇的血浆纤连蛋白（FN）水平进行了评估，以确定其是否为子痫前期的潜在危险因素。共有163名在卡拉巴尔大学教学医院产前诊所就诊的孕妇参与了该研究，60名非孕妇作为对照。约77名（47.24%）孕妇在孕期接受了子痫前期后续发展情况的随访。采用酶联免疫吸附测定法（ELISA）检测血浆中的纤连蛋白水平，并用分光光度法测定血清总蛋白、尿素和肌酐。非肥胖孕妇孕早期的平均血浆FN浓度比非孕妇低24%，但在孕中期和孕晚期升至非孕妇水平。肥胖/超重孕妇在孕中期和孕晚期的值显著高于非肥胖孕妇（P < 0.05）。肥胖/超重孕妇的FN与平均动脉血压呈正相关（MAP：r = 0.414，P = 0.04）。在妊娠18 - 24周时，FN高于330μg/ml临界值的孕妇中约28.57%发生了子痫前期。仅考虑肥胖/超重女性时，这一比例增至40.0%。对纤连蛋白>330μg/ml和MAP>90进行分析时，预测价值增至66.7%。因此，我们得出结论，FN升高可能被视为子痫前期的一个危险因素，尤其是在肥胖女性中。
