Department of Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
World J Gastroenterol. 2012 Mar 21;18(11):1249-56. doi: 10.3748/wjg.v18.i11.1249.
To investigate how a complex network of CC chemokine ligands (CCLs) and their receptors influence the progression of tumor and metastasis.
In the present study, we used immunohistochemistry to examine the expression of CCL7, CCL8 and CCL21 in 194 gastric cancer samples and adjacent normal tissues. We analyzed their correlation with tumor metastasis, clinicopathologic parameters and clinical outcome.
We found that the higher expression of CCL7 and CCL21 in cancer tissues than in normal tissues was significantly correlated with advanced depth of wall invasion, lymph node metastasis and higher tumor node metastasis stage. Moreover, Kaplan-Meier survival analysis revealed that CCL7 and CCL21 overexpression in cancer tissues was correlated with poor prognosis.
These results suggest that overexpression of these two CC chemokine ligands is associated with tumor metastasis and serves as a prognostic factor in patients with gastric cancer.
研究 CC 趋化因子配体 (CCLs) 及其受体的复杂网络如何影响肿瘤的进展和转移。
本研究采用免疫组织化学方法检测了 194 例胃癌组织及其相邻正常组织中 CCL7、CCL8 和 CCL21 的表达情况，并分析了它们与肿瘤转移、临床病理参数和临床预后的关系。
我们发现，与正常组织相比，胃癌组织中 CCL7 和 CCL21 的高表达与肿瘤浸润深度、淋巴结转移和肿瘤淋巴结转移分期较高显著相关。此外，Kaplan-Meier 生存分析显示，胃癌组织中 CCL7 和 CCL21 的过表达与预后不良相关。
这些结果表明，这两种 CC 趋化因子配体的过表达与肿瘤转移相关，并可作为胃癌患者的预后因素。
