University of Calgary, Department of Clinical Neurosciences, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada.
Expert Opin Drug Saf. 2012 May;11(3):487-502. doi: 10.1517/14740338.2012.677026. Epub 2012 Apr 3.
Pregabalin is an anticonvulsant with one known mechanism of action which is used most specifically in the management of neuropathic pain.
The adverse effect profile of this medication from controlled, randomized studies as well as open and long-term studies is described with consideration of the evidence-based results for pregabalin's clinical use.
Pregabalin is a mostly well tolerated medication for the management of neuropathic pain and other conditions. Pregabalin use is associated with benign central nervous system and systemic adverse effects with very limited metabolic, idiosyncratic, or teratogenic adverse effects. Understanding of these adverse effects is essential for the clinician treating the patient and for the patient receiving treatment. Sedation, dizziness, peripheral edema, and dry mouth are the most prevalent adverse events experienced in all clinical populations. Other adverse effects are rare, but are discussed.
普瑞巴林是一种具有一种已知作用机制的抗惊厥药物，主要用于治疗神经性疼痛。
本文描述了该药在对照、随机研究以及开放性和长期研究中的不良影响概况，并考虑了普瑞巴林临床应用的循证结果。
普瑞巴林是一种用于治疗神经性疼痛和其他疾病的药物，具有良好的耐受性。普瑞巴林的使用与良性中枢神经系统和全身不良事件相关，具有非常有限的代谢、特异质或致畸不良事件。了解这些不良事件对治疗患者的临床医生和接受治疗的患者至关重要。镇静、头晕、外周水肿和口干是所有临床人群中最常见的不良事件。其他不良反应罕见，但也有讨论。
