Erciyes University Medical Faculty, Internal Medicine Intensive Care Unit, Kayseri, Turkey.
Clin Toxicol (Phila). 2012 Jun;50(5):441-3. doi: 10.3109/15563650.2012.676647. Epub 2012 Apr 3.
We investigated the effects of endosulfan intoxication on pituitary functions in three patients.
This is an observational case series including three patients with endosulfan intoxication. Patients were evaluated 3 months after the acute event.
Based on the baseline hormonal values and dynamic endocrine tests, one patient had hypothalamo-pituitary-adrenal axis impairment and was diagnosed as ACTH deficiency (peak cortisol level was found 13.12 μg/dl after low dose ACTH stimulation test), and another one had GH-IGF-I axis impairment and was diagnosed as GH deficiency (peak GH level was found 1.06 μg/L after glucagon stimulation test).
Endosulfan intoxication might cause pituitary hormone deficiencies after the acute phase. Therefore, patients with endosulfan toxicity should be followed for possible pituitary gland dysfunction.
我们研究了三例患者中，硫丹中毒对垂体功能的影响。
这是一个包括 3 例硫丹中毒患者的观察性病例系列。患者在急性事件后 3 个月接受评估。
根据基础激素值和动态内分泌检查，1 例患者存在下丘脑-垂体-肾上腺轴功能障碍，被诊断为 ACTH 缺乏症（小剂量 ACTH 刺激试验后皮质醇峰值水平为 13.12μg/dl），另 1 例患者存在 GH-IGF-I 轴功能障碍，被诊断为 GH 缺乏症（胰高血糖素刺激试验后 GH 峰值水平为 1.06μg/L）。
硫丹中毒后可能会导致急性后期的垂体激素缺乏。因此，硫丹中毒的患者应定期随访，以发现可能存在的垂体功能障碍。
