Grant-Webster K S, Gunderson V M, Brubacher T M
Department of Psychology, University of Washington, Seattle 98195.
Neurotoxicol Teratol. 1990 Sep-Oct;12(5):543-6. doi: 10.1016/0892-0362(90)90020-d.
The Infant Primate Research Laboratory at the University of Washington utilizes a range of test procedures to study perceptual-cognitive development in nonhuman primate infants at high and low risk for poor developmental outcome. These test procedures rely on the visual preferences of infants and are employed in research with both human and animal subjects. The forced-choice preferential looking technique is based on the primate infants' preference for patterned over plain stimuli and allows the early measurement of visual acuity. The novelty paradigm is based on the preference that infants show for novel over familiar stimuli and is used to study intramodal and cross-modal recognition memory. Tests of recognition memory have shown sensitivity in detecting subtle functional alterations associated with perinatal risk factors such as teratogen exposure. The use of measures which assess early patterns of visual attention should be considered in both human and nonhuman primate studies in behavioral teratology.
华盛顿大学的灵长类动物婴儿研究实验室运用一系列测试程序，来研究发育结果不佳风险高低不同的非人类灵长类动物婴儿的感知认知发展。这些测试程序依赖于婴儿的视觉偏好，并且用于人类和动物受试者的研究中。强制选择优先注视技术基于灵长类动物婴儿对有图案刺激优于无图案刺激的偏好，可用于早期视力测量。新奇范式基于婴儿对新奇刺激优于熟悉刺激的偏好，用于研究模态内和跨模态识别记忆。识别记忆测试已显示出在检测与围产期风险因素（如接触致畸剂）相关的细微功能改变方面具有敏感性。在行为致畸学的人类和非人类灵长类动物研究中，都应考虑使用评估早期视觉注意模式的测量方法。
