Suppr超能文献

[基因检测对心血管疾病预防有用吗?]

[Are genetic tests useful for cardiovascular prevention?].

作者信息

Bochud Murielle, Fellmann Florence, Guessous Idris

机构信息

Unité de prévention communautaire, Institut de médecine sociale et préventive, CHUV, 1011 Lausanne.

出版信息

Rev Med Suisse. 2012 Mar 7;8(331):519-20, 522-4.

Abstract

Recent progresses in genetics have opened new avenues to further our understanding of the pathophysiological mechanisms underlying cardiovascular disease, raising, new expectations in the field of personalized medicine. Genetic tests may have a high predictive value for rare monogenic diseases. The situation is very different for common polygenic diseases, such as myocardial infarction, type 2 diabetes or stroke. The results from recent genome-wide association studies have provided useful information for research, but have not yet been proven to be clinically useful. It is therefore currently not recommended to conducted genetic testing to guide cardiovascular prevention neither in clinical nor in public health settings.

摘要

遗传学的最新进展为我们进一步了解心血管疾病的病理生理机制开辟了新途径,也在个性化医疗领域引发了新的期望。基因检测对罕见单基因疾病可能具有较高的预测价值。对于常见的多基因疾病,如心肌梗死、2型糖尿病或中风,情况则大不相同。近期全基因组关联研究的结果为研究提供了有用信息,但尚未被证明具有临床实用性。因此,目前无论是在临床还是公共卫生环境中,都不建议进行基因检测以指导心血管疾病的预防。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验