Dvivedi Jyoti, Pandey S, Gupta R
Department of Physiology, Himalaya Institute of Medical Sciences, Swami Ram Nagar, Jollygrant, Dehradun - 248 140.
Indian J Physiol Pharmacol. 2011 Jul-Sep;55(3):207-12.
Curcumin derived from the rhizome Curcuma longa is one of the primary ingredient in turmeric. Turmeric is used frequently as food additive in Asia, specially the Indian subcontinent. The daily intake of turmeric in the diet may therefore expose the gut to curcumin and affect its physiological functions, including the absorption of nutrients from small intestine. However, no published reports are available on the effect curcumin on absorption of nutrients from small intestine. To explore this possibility, transport of glucose from small intestine was studied in adult albino rats following feeding the animals curcumin intragastrically for five consecutive days. The controls were fed simultaneously, the vehicular fluid intragastrically in the identical volume. Transport of glucose from small intestine was studied using everted sac technique of Wilson and Wiseman (1954) on animals fasted for 16-20 hrs. Everted sacs were prepared from both jejunal and ileal portion of small intestine. Observations showed a significant increase in glucose transport from jejunal and upper ileal portion of small intestine suggesting that curcumin does influence the transport of nutrients from the gut.
源自姜黄根茎的姜黄素是姜黄的主要成分之一。在亚洲，尤其是印度次大陆，姜黄常被用作食品添加剂。因此，日常饮食中摄入的姜黄可能会使肠道接触到姜黄素，并影响其生理功能，包括小肠对营养物质的吸收。然而，目前尚无关于姜黄素对小肠营养物质吸收影响的公开报道。为了探究这种可能性，在成年白化大鼠连续五天经胃内给予姜黄素后，研究了小肠对葡萄糖的转运情况。对照组同时经胃内给予相同体积的赋形剂溶液。采用Wilson和Wiseman（1954年）的外翻肠囊技术，对禁食16 - 20小时的动物进行小肠葡萄糖转运研究。从小肠空肠和回肠部分制备外翻肠囊。观察结果显示，小肠空肠和回肠上段的葡萄糖转运显著增加，这表明姜黄素确实会影响肠道对营养物质的转运。
