Purwar Brijesh, Shrivastava Abha, Arora Neetu, Kumar Anil, Saxena Yogesh
Department of Physiology, Himalayan Institute of Medical Sciences, Jolly Grant, Dehradun - 248 140.
Indian J Physiol Pharmacol. 2012 Apr-Jun;56(2):168-73.
Curcumin (diferuloylmethane), a polyphenol, is an active principle of the perennial herb Curcuma longa commonly known as turmeric. Turmeric (CURCUMA LONGA L.) is a medicinal plant extensively used in Ayurveda, Unani, and Siddha medicine as a home remedy for various diseases including biliary diseases, cough, hepatic diseases, wound healing. However studies on the effect of curcumin on the gastric emptying are nearly nonexistent. It is hypothesized that curcumin may have an effect on gastric emptying. For this reason the present study was aimed to study the effect of curcumin on gastric emptying. Rats were divided into 5 groups (Group I - Group V), based on the time interval between administration of curcumin/vehicular fluid to administration of barium sulphate (Group I - 1 hr, Group II - 8 hrs, Group III - 16 hrs, Group IV - 24 hrs, Group V - 48 hrs). Each group was further divided into two subgroups, Group A (control) and Group B (experimental), containing 6 rats each. Rats in experimental group were administered curcumin intragastrically, in the dose of 1 gm/kg body weight, suspended in normal saline (0.9% NaCl). The controls were given vehicular fluid intragastrically, in volume equal to the experimental animals. It was observed that there was a decrease in the gastric emptying in all the experimental groups.
姜黄素（二阿魏酰甲烷）是一种多酚，是多年生草本植物姜黄（俗称姜黄）的活性成分。姜黄（CURCUMA LONGA L.）是一种药用植物，在阿育吠陀医学、尤那尼医学和悉达医学中被广泛用作治疗各种疾病的家庭疗法，包括胆道疾病、咳嗽、肝脏疾病和伤口愈合。然而，关于姜黄素对胃排空影响的研究几乎不存在。据推测，姜黄素可能对胃排空有影响。因此，本研究旨在研究姜黄素对胃排空的影响。根据给予姜黄素/赋形剂液体至给予硫酸钡之间的时间间隔，将大鼠分为5组（I组 - V组）（I组 - 1小时，II组 - 8小时，III组 - 16小时，IV组 - 24小时，V组 - 48小时）。每组进一步分为两个亚组，A组（对照组）和B组（实验组），每组各有6只大鼠。实验组大鼠经胃内给予姜黄素，剂量为1克/千克体重，悬浮于生理盐水（0.9% NaCl）中。对照组经胃内给予赋形剂液体，体积与实验动物相同。观察到所有实验组的胃排空均有所下降。
