Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
FEMS Microbiol Lett. 2012 Jul;332(1):1-9. doi: 10.1111/j.1574-6968.2012.02566.x. Epub 2012 May 3.
Intracellular pathogens like Salmonella evade host phagocytic killing by various mechanisms. Classical antimicrobial therapy requires multiple dosages and frequent administration of drugs for a long duration. Intracellular delivery of antimicrobials using nanoparticle may effectively devise therapies for bacterial infections. This review will address the mechanisms used by Salmonella to avoid host pathogenic killing, reasons for therapeutic failure and advances in nanoparticle drug delivery technology for efficient intracellular bacterial clearance.
细胞内病原体（如沙门氏菌）通过各种机制逃避宿主吞噬细胞的杀伤。传统的抗菌治疗需要多次给药，并且需要长时间频繁使用药物。利用纳米颗粒进行抗菌药物的细胞内递药可能会有效地设计针对细菌感染的治疗方法。本文综述了沙门氏菌逃避宿主致病性杀伤的机制、治疗失败的原因，以及纳米颗粒药物递送技术在有效清除细胞内细菌方面的进展。
