Centre for Education and Research on Ageing, Concord Hospital and University of Sydney, Sydney, NSW.
Med J Aust. 2012 Apr 2;196(6):395-8. doi: 10.5694/j.1326-5377.2012.tb04214.x.
To describe values of serum prostate-specific antigen (PSA) in older men without diagnosed prostate cancer, categorised by age and country of birth, and to describe self-reported prostate cancer screening.
DESIGN, PARTICIPANTS AND SETTING: A cohort study (the Concord Health and Ageing in Men Project) involving a representative sample of 1434 eligible community-dwelling men with no diagnosis of prostate cancer who were aged 70 years and over and living in a defined geographic area in Sydney, with baseline data collected between 28 January 2005 and 4 June 2007.
Serum PSA levels and self-reported prostate cancer screening.
11% of men (155) had a PSA level of ≥6.5 ng/mL, increasing from 7.5% of men aged 70-74 years to 31.4% of men aged≥90 years. PSA levels varied with ethnicity, with Australian-born men (695) having the highest levels (median, 2.3 ng/mL; 5th-95th percentile, 0.4-10.1 ng/mL), followed by men born in China (n=42; 2.1 ng/mL; 0.4-12.4 ng/mL), United Kingdom and Ireland (n=70; 1.9 ng/mL; 0.3-8.9 ng/mL), Greece (n=59; 1.5 ng/mL; 0.2-6.1 ng/mL), and Italy (n=293; 1.4 ng/mL; 0.3-7.2 ng/mL). A PSA test in the previous 2 years was reported by 48% of participants, and a digital rectal examination (DRE) in the previous 2 years by 37%.
A significant number of men aged over 70 years reported recent prostate cancer tests. The PSA level ranges reported in this cohort will help with interpreting serum PSA level findings in men aged over 70 years.
描述无前列腺癌诊断的老年男性（按年龄和出生国分类）的血清前列腺特异性抗原（PSA）值，并描述自述的前列腺癌筛查情况。
设计、参与者和设置：这是一项队列研究（Concord 健康与老龄化男性项目），涉及一个具有代表性的 1434 名符合条件的社区居住的 70 岁及以上且居住在悉尼一个特定地理区域的无前列腺癌诊断的男性，基线数据收集于 2005 年 1 月 28 日至 2007 年 6 月 4 日之间。
血清 PSA 水平和自述的前列腺癌筛查。
11%的男性（155 人）的 PSA 水平≥6.5ng/mL，从 70-74 岁男性的 7.5%增加到≥90 岁男性的 31.4%。PSA 水平因种族而异，澳大利亚出生的男性（695 人）的 PSA 水平最高（中位数为 2.3ng/mL；5%至 95%百分位数为 0.4-10.1ng/mL），其次是中国出生的男性（42 人；2.1ng/mL；0.4-12.4ng/mL）、英国和爱尔兰出生的男性（70 人；1.9ng/mL；0.3-8.9ng/mL）、希腊出生的男性（59 人；1.5ng/mL；0.2-6.1ng/mL）和意大利出生的男性（293 人；1.4ng/mL；0.3-7.2ng/mL）。48%的参与者报告在过去 2 年内进行了 PSA 检测，37%的参与者报告在过去 2 年内进行了直肠指检（DRE）。
相当数量的 70 岁以上男性报告了最近的前列腺癌检测。本队列报告的 PSA 水平范围将有助于解释 70 岁以上男性的血清 PSA 水平结果。
