Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria.
Vox Sang. 2012 Oct;103(3):194-200. doi: 10.1111/j.1423-0410.2012.01609.x. Epub 2012 Apr 4.
Multicomponent collection (MCC) enables production and processing of various blood components during one apheresis session. In this prospective crossover study, the effects of donating platelets (PLTs) and packed red blood cells (PRBCs) on donor's blood cell count, coagulation, PLT function and iron state were analysed.
Forty-eight MCCs were performed using two different cell separators (Fenwal Amicus(®), CaridianBCT Trima Accel(®)). Two units of platelet concentrates and one unit of PRBCs were collected during each session. Full blood cell count and iron status were obtained on day 0 before and after apheresis, day 2, day 14 and day 42. PLT function was analysed by aggregometry and rotation thromboelastometry in parallel with coagulation tests before and after MCC and at day 2.
Multicomponent collection was well tolerated without adverse side effects. Blood cell count and iron parameters declined and most of them (haemoglobin, haematocrit, transferrin, transferrin saturation and ferritin) were significantly below baseline values until at least day 42 after donation. Absent iron stores were seen in 31·3% of the donors. In contrast, PLTs significantly exceeded pre-donation values after 14 days and remained significantly increased for 42 days. After 2 days, coagulation parameters were only slightly (P > 0·05) altered, whereas PLT function was significantly reduced.
Multicomponent collection is an obviously safe procedure; however, the significant long-term impact on the donor's blood count and iron store, as well as impaired PLT function, has to be considered in regard to donor safety.
多组分采集（MCC）可在一次单采过程中生产和处理各种血液成分。在这项前瞻性交叉研究中，分析了捐献血小板（PLT）和浓缩红细胞（PRBC）对供者血细胞计数、凝血、PLT 功能和铁状态的影响。
使用两台不同的细胞分离机（费森尤斯 Amicus（®）、卡利迪安 BCT Trima Accel（®））进行了 48 次 MCC。每次采集 2 个单位的血小板浓缩物和 1 个单位的 PRBC。在采集前、采集后第 0 天、第 2 天、第 14 天和第 42 天获得全血细胞计数和铁状态。在 MCC 前后以及第 2 天，通过聚集仪和旋转血栓弹性图平行分析 PLT 功能，并同时进行凝血试验。
MCC 耐受良好，无不良反应。血细胞计数和铁参数下降，其中大多数（血红蛋白、血细胞比容、转铁蛋白、转铁蛋白饱和度和铁蛋白）在捐赠后至少 42 天内明显低于基线值。31.3%的供者出现缺铁。相反，PLT 在 14 天后明显超过了捐献前的值，并在 42 天内持续显著增加。在第 2 天，凝血参数仅略有变化（P > 0.05），而 PLT 功能明显降低。
MCC 是一种明显安全的程序；然而，在考虑供者安全性时，必须考虑到对供者的血细胞计数和铁储存以及 PLT 功能受损的显著长期影响。
