Kim Gun-Wook, Park Hyun-Je, Kim Hoon-Soo, Chin Hyun-Woo, Kim Su-Han, Ko Hyun-Chang, Kim Moon-Bum, Kim Byung-Soo
Department of Dermatology, Pusan National University, School of Medicine, Busan, Korea.
Pediatr Dermatol. 2013 Mar-Apr;30(2):256-9. doi: 10.1111/j.1525-1470.2012.01744.x. Epub 2012 Apr 4.
Although papulonecrotic tuberculid is an uncommon cutaneous manifestation of tuberculosis (TB) associated with Mycobacterium tuberculosis infection, the simultaneous occurrence of papulonecrotic tuberculid and erythema induratum is even rarer. Papulonecrotic tuberculid occurs predominantly in young adults and is characterized by eruptions of necrotizing papules that heal with varioliform scars. Histopathologic findings include wedge-shaped necrosis of the dermis, poorly formed granulomatous infiltration, and vasculitis. Stainings and culture for acid-fast bacilli from skin biopsies are usually negative for M. tuberculosis, although the eruptions resolve with antitubercular therapy. Few patients with papulonecrotic tuberculid, especially with concurrent occurrence of erythema induratum, have been reported in the English literature. Here we report a case of a 12-year-old girl with simultaneous occurrence of papulonecrotic tuberculid and erythema induratum accompanying pulmonary TB.
虽然丘疹坏死性结核疹是与结核分枝杆菌感染相关的一种不常见的肺结核皮肤表现,但丘疹坏死性结核疹和硬结性红斑同时出现的情况更为罕见。丘疹坏死性结核疹主要发生于年轻人,其特征为坏死性丘疹疹,愈后留有痘疮样瘢痕。组织病理学表现包括真皮楔形坏死、肉芽肿形成不良及血管炎。虽然皮肤活检的抗酸杆菌染色和培养通常未发现结核分枝杆菌,但经抗结核治疗后皮疹可消退。英文文献中报道的丘疹坏死性结核疹患者很少,尤其是同时合并硬结性红斑的患者。在此,我们报告一例12岁女孩,其同时出现丘疹坏死性结核疹和硬结性红斑,并伴有肺结核。