State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Org Lett. 2012 Apr 20;14(8):2010-3. doi: 10.1021/ol300510b. Epub 2012 Apr 3.
The combination of a chiral phosphate anion with a silver ion has been demonstrated as a powerful and synergistic ion pair catalyst for the aza-Mannich reaction. A series of valuable quaternary α,β-diamino acid derivatives was obtained in high yield, and with excellent diastereo- (up to 25:1 dr) and enantioselectivity (up to 99% ee). The adducts can be smoothly transformed into the corresponding protected chiral quaternary α,β-diamino acids by a one-pot hydrolysis reaction.
手性磷酸阴离子与银离子的组合已被证明是一种强大且协同的离子对催化剂，可用于氮杂-Mannich 反应。通过该方法可以高收率、优异的非对映选择性（高达 25:1 dr）和对映选择性（高达 99%ee）获得一系列有价值的季碳 α,β-二氨基酸衍生物。通过一锅水解反应，加成产物可以顺利转化为相应的保护手性季碳 α,β-二氨基酸。
