Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663 North Zhongshan Rd., Shanghai, 200062, China.
Chem Commun (Camb). 2013 May 14;49(39):4238-40. doi: 10.1039/c3cc36972b. Epub 2013 Jan 29.
A highly enantioselective trapping of protic phosphoramidate ammonium ylides with α-imino esters is reported. The intriguing Rh2(OAc)4 and chiral Brønsted acid co-catalyzed three-component Mannich-type reaction of a diazo compound, a phosphoramidate, and an α-imino ester provides a rapid and efficient access to 2,3-diaminosuccinic acid derivatives with a high level control of diastereo- and enantioselectivity.
本文报道了质子化磷酰胺铵叶立德与α-亚氨基酯的高对映选择性捕获。有趣的是，Rh2(OAc)4 和手性 Brønsted 酸共同催化了重氮化合物、磷酰胺和α-亚氨基酯的三组分 Mannich 型反应，为 2,3-二氨基琥珀酸衍生物提供了一种快速高效的合成方法，具有高非对映选择性和对映选择性控制。
