Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
Environ Health. 2012 Apr 2;11:21. doi: 10.1186/1476-069X-11-21.
Phthalates, commonly used to soften plastic goods, are known PPAR-agonists affecting lipid metabolism and adipocytes in the experimental setting. We evaluated if circulating concentrations of phthalates were related to different indices of obesity using data from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Data from both dual-energy X-ray absorptiometry (DXA) and abdominal magnetic resonance imaging (MRI) were used.
1,016 subjects aged 70 years were investigated in the PIVUS study. Four phthalate metabolites were detected in the serum of almost all subjects (> 96%) by an API 4000 liquid chromatograph/tandem mass spectrometer. Abdominal MRI was performed in a representative subsample of 287 subjects (28%), and a dual-energy X-ray absorptiometry (DXA)-scan was obtained in 890 (88%) of the subjects two year following the phthalate measurements.
In women, circulating concentrations of mono-isobutyl phthalate (MiBP) were positively related to waist circumference, total fat mass and trunk fat mass by DXA, as well as to subcutaneous adipose tissue by MRI following adjustment for serum cholesterol and triglycerides, education, smoking and exercise habits (all p < 0.008). Mono-methyl phthalate (MMP) concentrations were related to trunk fat mass and the trunk/leg-ratio by DXA, but less powerful than MiBP. However, no such statistically significant relationships were seen in men.
The present evaluation shows that especially the phthalate metabolite MiBP was related to increased fat amount in the subcutaneous abdominal region in women measured by DXA and MRI two years later.
邻苯二甲酸酯常用于软化塑料制品，已知其为影响实验环境中脂质代谢和脂肪细胞的过氧化物酶体增殖物激活受体（PPAR）激动剂。我们使用 Prospective Investigation of the Vasculature in Uppsala Seniors（PIVUS）研究的数据，评估了循环邻苯二甲酸酯浓度与肥胖的不同指标之间的关系。该研究同时使用了双能 X 射线吸收法（DXA）和腹部磁共振成像（MRI）的数据。
在 PIVUS 研究中，对 1016 名年龄在 70 岁的受试者进行了研究。通过 API 4000 液相色谱/串联质谱仪，几乎所有受试者（>96%）的血清中均检测到了 4 种邻苯二甲酸酯代谢物。在 287 名受试者（28%）的代表性亚样本中进行了腹部 MRI 检查，并且在邻苯二甲酸酯测量两年后，在 890 名受试者（88%）中获得了双能 X 射线吸收法（DXA）扫描。
在女性中，循环中单异丁基邻苯二甲酸酯（MiBP）浓度与 DXA 测量的腰围、总脂肪量和躯干脂肪量以及 MRI 测量的皮下脂肪组织呈正相关，并且在校正血清胆固醇和甘油三酯、教育、吸烟和运动习惯后仍具有统计学意义（均 p <0.008）。邻苯二甲酸单甲酯（MMP）浓度与 DXA 测量的躯干脂肪量和躯干/下肢比值相关，但不如 MiBP 相关度高。然而，在男性中未观察到这种具有统计学意义的关系。
本评估表明，特别是邻苯二甲酸酯代谢物 MiBP 与女性 2 年后通过 DXA 和 MRI 测量的腹部皮下区域脂肪量增加有关。
