Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Exp Cell Res. 2012 Jul 15;318(12):1386-93. doi: 10.1016/j.yexcr.2012.03.016. Epub 2012 Mar 24.
Cells use ring-like structured protein complexes for various tasks in DNA dynamics. The tripartite cohesin ring is particularly suited to determine chromosome architecture, for it is large and dynamic, may acquire different forms, and is involved in several distinct nuclear processes. This review focuses on cohesin's role in structuring chromosomes during mitotic and meiotic cell divisions and during interphase.
细胞利用环状结构的蛋白复合物来完成 DNA 动态过程中的各种任务。三联体黏合蛋白环特别适合决定染色体的结构，因为它体积大、有活性，可以形成不同的构象，并且参与了几种不同的核过程。这篇综述主要关注黏合蛋白在有丝分裂和减数分裂以及细胞间期过程中对染色体结构的作用。
