University of Rochester School of Medicine and Dentistry, Department of Community and Preventive Medicine, Rochester, NY 14642-0644, USA.
Prostaglandins Leukot Essent Fatty Acids. 2012 Apr;86(4-5):155-60. doi: 10.1016/j.plefa.2012.03.003. Epub 2012 Apr 1.
Fish is the primary source of dietary omega-3 poly-unsaturated fatty acids EPA and DHA, which have been reported to reduce depressive symptoms in clinical trials. We assessed the association between fish consumption and depressive symptoms in a nationally representative sample of 10,480 adults from the 2005-2008 National Health and Nutrition Examination Survey. Depressive symptoms were classified by severity using the Patient Health Questionnaire. Fish meal consumption reported in 30-day food frequency questionnaires, and EPA+DHA intake computed from 24-h dietary recalls were evaluated in relation to depressive symptoms using multivariable ordinal logistic regression. Consumption of breaded fish showed an increased risk of greater depressive symptom severity, while all fish, non-breaded fish, and shell fish were not associated. Any EPA+DHA intake was significantly associated with fewer depressive symptoms. Exposure-response analyses revealed no clear patterns for any intake measures. Inconsistent patterns of associations in our study may be partially explained by exposure misclassification.
鱼类是膳食ω-3 多不饱和脂肪酸 EPA 和 DHA 的主要来源，临床试验已经证实这些脂肪酸可以减轻抑郁症状。我们利用 2005-2008 年全国健康与营养调查中 10480 名成年人的全国代表性样本评估了鱼类摄入量与抑郁症状之间的关系。采用患者健康问卷对抑郁症状的严重程度进行分类。通过 30 天食物频率问卷报告的鱼粉摄入量和 24 小时膳食回顾计算的 EPA+DHA 摄入量，采用多变量有序逻辑回归评估与抑郁症状的关系。用面糊包裹的鱼的食用量与更严重的抑郁症状严重程度呈正相关，而所有鱼类、非面糊鱼和贝类与抑郁症状无关。任何 EPA+DHA 的摄入量与较少的抑郁症状显著相关。暴露反应分析没有显示出任何摄入措施的明确模式。我们研究中关联模式的不一致可能部分归因于暴露分类错误。
