Hospital for Small Animals, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK.
Vet Rec. 2012 May 19;170(20):518. doi: 10.1136/vr.100289. Epub 2012 Apr 2.
Laryngeal saccule eversion has been widely reported as an important component of brachycephalic airway obstructive syndrome (BAOS). The authors hypothesised that saccules affected by acute histological changes in patients showing marked improvement following palate and nares surgery might spontaneously return to normal; moreover, spontaneous resolution of the eversion in patients with fibrotic saccules and/or without clinical improvement following BAOS surgery might be impossible and, on the contrary, the persistence of turbulent airflow and associated ongoing inflammation might lead to aberrant tissue proliferation after resection. In order to demonstrate our hypotheses, the authors decided to perform a unilateral sacculectomy and to postpone and assess the need for the execution of the contralateral saccule resection according to the findings of a second-look laryngoscopy. Ten dogs were enrolled. None of the saccules left in situ underwent spontaneous resolution of the eversion. In one dog, after sacculectomy, proliferation of a soft tissue lesion endoscopically similar to a newly formed saccule occurred. The results of the present study suggest that spontaneous resolution of saccule eversion is uncommon, even after the correction of the primary abnormalities (palate, nares). Resection of the saccules can relieve ventral rima glottidis obstruction; however, secondary intention healing might occasionally result in the recurrence of the obstruction.
喉囊外翻已被广泛报道为短头型气道阻塞综合征（BAOS）的一个重要组成部分。作者假设，在接受腭和鼻腔手术治疗后表现出明显改善的患者中，受急性组织学变化影响的囊体会自发恢复正常；此外，纤维化囊和/或 BAOS 手术后无临床改善的患者的外翻自发缓解可能是不可能的，相反，湍流气流的持续存在和相关的持续炎症可能会导致切除后异常组织增生。为了验证我们的假设，作者决定进行单侧囊切除术，并根据第二次喉镜检查的结果推迟并评估对侧囊切除术的执行必要性。10 只狗被纳入研究。未进行手术的囊均未自发缓解外翻。在一只狗中，囊切除术后，会出现一个类似于新形成的囊的软组织病变的增生。本研究结果表明，即使在纠正主要异常（腭、鼻腔）后，囊外翻的自发缓解也不常见。囊切除术可以缓解声门下裂腹侧的阻塞；然而，二次愈合偶尔可能导致阻塞的复发。
