Leeds Gastroenterology Institute, St James's University Hospital, UK.
Am J Gastroenterol. 2012 Jun;107(6):912-21. doi: 10.1038/ajg.2012.69. Epub 2012 Apr 3.
Most chronic and recurrent gastrointestinal (GI) symptoms in the community are caused by functional GI disorders, such as functional dyspepsia and irritable bowel syndrome (IBS). It is not known, however, whether these conditions affect mortality. We present the results of a large community-based prospective study that examines this issue.
This was a 10-year follow-up, conducted in 2004, of individuals recruited into a community-based screening program for Helicobacter pylori. Data on mortality and cause of death at 10 years were obtained from the Office for National Statistics. Baseline demographic data, lifestyle factors, GI symptoms, and quality of life were recorded at study entry. The effect of all these factors on 10-year mortality was examined using univariate analysis and multivariate Cox regression analysis. All results were expressed as hazard ratios (HRs) with 99% confidence intervals (CIs).
Symptom data were available for 8,323 (99.0%) of 8,407 individuals originally enrolled, comprising over 84,000 years of follow-up: 3,169 (38.1%) subjects had dyspepsia, and 264 (3.2%) IBS. There were 137 (1.65%) individuals who had died at 10 years. After multivariate analysis, there was no significant difference in likelihood of death at 10 years in those with dyspepsia (HR: 0.94; 99% CI: 0.58-1.54) or IBS (HR: 1.35; 99% CI: 0.36-5.10), compared with those not meeting the criteria for either condition.
Dyspepsia was not associated with an increased mortality in the community. Data for any effect of IBS on survival were less clear. Further studies are required to assess the impact of functional GI disorders on life expectancy.
社区中大多数慢性和复发性胃肠道（GI）症状是由功能性 GI 疾病引起的，例如功能性消化不良和肠易激综合征（IBS）。然而，尚不清楚这些病症是否会影响死亡率。我们呈现了一项大型社区前瞻性研究的结果，该研究探讨了这个问题。
这是一项针对在社区为幽门螺杆菌进行筛查计划中招募的个体进行的为期 10 年的随访研究，于 2004 年进行。通过国家统计局获得了 10 年时的死亡率和死因数据。在研究开始时记录了基线人口统计学数据、生活方式因素、GI 症状和生活质量。使用单变量分析和多变量 Cox 回归分析检查了所有这些因素对 10 年死亡率的影响。所有结果均以危险比（HR）和 99%置信区间（CI）表示。
最初纳入的 8407 名个体中有 8323 名（99.0%）提供了症状数据，涵盖了超过 84000 年的随访期：3169 名（38.1%）患者患有消化不良，264 名（3.2%）患有 IBS。10 年内有 137 名（1.65%）个体死亡。经过多变量分析，患有消化不良（HR：0.94；99%CI：0.58-1.54）或 IBS（HR：1.35；99%CI：0.36-5.10）的个体在 10 年内死亡的可能性与不符合这两种病症标准的个体相比，没有显著差异。
消化不良与社区中的死亡率增加无关。关于 IBS 对生存的任何影响的数据不太明确。需要进一步研究来评估功能性 GI 疾病对预期寿命的影响。
