Ford A C, Forman D, Bailey A G, Axon A T R, Moayyedi P
Centre for Digestive Diseases, Leeds General Infirmary, Leeds, UK.
Aliment Pharmacol Ther. 2008 Oct 15;28(8):1013-20. doi: 10.1111/j.1365-2036.2008.03813.x. Epub 2008 Jul 24.
There are few studies examining the stability of gastrointestinal symptoms during prolonged periods of follow-up.
To examine this issue in individuals previously recruited into a community screening programme for Helicobacter pylori providing symptom data at study entry.
All traceable participants were sent dyspepsia and IBS questionnaires by post at 10 years. Symptom subgroups were assigned at baseline and 10-year follow-up. Individuals symptomatic at both time points who changed subgroup were compared with those symptomatic and remaining in the same subgroup.
Three-thousand eight hundred and nineteen individuals provided data. At baseline, 2417 (63%) were asymptomatic or did not meet diagnostic criteria for a subgroup. Of these, 1648 (68%) remained asymptomatic at 10 years, whilst 769 (32%) reported symptoms. Of the 1402 individuals symptomatic at baseline, 404 (29%) remained in the same subgroup at 10 years, 603 (43%) changed subgroup and symptoms resolved or did not meet criteria for a subgroup in 395 (28%). Symptom stability was more likely in males [odds ratio (OR): 1.50; 99% confidence interval (CI): 0.97-2.31] and older subjects (OR per year: 1.09; 99% CI: 1.01-1.17).
Of those subjects symptomatic at baseline, almost three-quarters remained symptomatic at 10 years, but over 40% changed symptom subgroup.
很少有研究在长期随访期间检查胃肠道症状的稳定性。
在先前纳入幽门螺杆菌社区筛查计划且在研究入组时提供症状数据的个体中研究此问题。
在10年时通过邮寄向所有可追踪的参与者发送消化不良和肠易激综合征问卷。在基线和10年随访时分配症状亚组。比较在两个时间点均有症状且亚组发生变化的个体与有症状且仍处于同一亚组的个体。
3819人提供了数据。在基线时，2417人（63%）无症状或未达到亚组诊断标准。其中，1648人（68%）在10年时仍无症状，而769人（32%）报告有症状。在基线时有症状的1402人中，404人（29%）在10年时仍处于同一亚组，603人（43%）亚组发生变化，395人（28%）症状缓解或未达到亚组标准。男性[优势比（OR）：1.50；99%置信区间（CI）：0.97 - 2.31]和年龄较大的受试者（每年OR：1.09；99% CI：1.01 - 1.17）症状更可能稳定。
在基线时有症状的受试者中，近四分之三在10年时仍有症状，但超过40%的人症状亚组发生了变化。
