Laboratory of Retrovirology, Howard Hughes Medical Institute, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA.
AIDS. 2012 Jun 19;26(10):1243-54. doi: 10.1097/QAD.0b013e328353bd04.
Many studies have documented how extensively HIV-1 and related viruses interact with host cells. Virus-host interactions are of two conceptual types. First, viruses have evolved to make use of numerous host-cell functions to facilitate their own replication. Second, hosts have evolved a number of activities to inhibit virus replication. Understanding the scope and details of HIV-host interactions has been an extraordinary rich scientific endeavor, and in addition to their biomedical importance, studies in this area have established HIV as a model system in virology. Here, I present an overview of how HIV-1 interacts with some key host cell factors during its replication cycle.
许多研究已经记录了 HIV-1 和相关病毒与宿主细胞相互作用的广泛程度。病毒-宿主相互作用有两种概念类型。首先，病毒已经进化出利用宿主细胞的许多功能来促进自身的复制。其次，宿主已经进化出许多活动来抑制病毒的复制。了解 HIV-宿主相互作用的范围和细节一直是一项非常丰富的科学努力，除了它们在生物医学上的重要性之外，该领域的研究还将 HIV 确立为病毒学的模型系统。在这里，我概述了 HIV-1 在其复制周期中与一些关键宿主细胞因子相互作用的方式。
