基质金属蛋白酶-2 和基质金属蛋白酶-9 在正常黏膜中与结直肠癌患者的预后独立相关。
MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients.
机构信息
Department of Gastroenterology-Hepatology, Leiden University Medical Centre, The Netherlands.
出版信息
Br J Cancer. 2012 Apr 24;106(9):1495-8. doi: 10.1038/bjc.2012.80.
BACKGROUND
Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients.
METHODS
We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease.
RESULTS
A high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (-1306C>T) and MMP-9 (-1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification.
CONCLUSION
MMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients.
背景
在各种癌症中，基质金属蛋白酶 MMP-2 和 MMP-9 的上调与患者的生存预后较差相关。
方法
我们评估了 MMP-2 和 MMP-9 水平在结直肠癌患者的正常结直肠黏膜中的表达与疾病进程的关系。
结果
发现正常黏膜中 MMP-2 和 MMP-9 的高蛋白表达与较差的 5 年生存率相关。这两个参数的组合是一个更强的预后因素。这些蛋白水平与 MMP-2（-1306C>T）和 MMP-9（-1562C>T）的相应单核苷酸多态性无关。多变量分析表明，正常黏膜中的 MMP-2 和 MMP-9 水平是生存的预后因素，独立于 TNM 分类。
结论
MMP-2 和 MMP-9 在正常结直肠黏膜中的水平可预示结直肠癌患者的疾病进程。
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