自噬、心肌保护与代谢综合征。
Autophagy, myocardial protection, and the metabolic syndrome.
机构信息
Department of Biology, Donald P. Shiley BioScience Center, San Diego State University, San Diego, CA 92182-4650, USA.
出版信息
J Cardiovasc Pharmacol. 2012 Aug;60(2):125-32. doi: 10.1097/FJC.0b013e318256ce10.
Abstract
Autophagy is a housekeeping process that helps to maintain cellular energy homeostasis and remove damaged organelles. In the heart, autophagy is an adaptive process that is activated in response to stress including acute and chronic ischemia. Given the evidence that autophagy is suppressed in energy-rich conditions, the objective of this review is to examine autophagy and cardioprotection in the setting of the metabolic syndrome. Clinical approaches that involve the induction of cardiac autophagy pharmacologically to enhance the heart's tolerance to ischemia are also discussed.
摘要
自噬是一种有助于维持细胞能量平衡和清除受损细胞器的细胞内自我降解过程。在心脏中，自噬是一种适应性过程，可在包括急性和慢性缺血在内的应激条件下被激活。鉴于自噬在富含能量的条件下受到抑制的证据，本综述的目的是在代谢综合征背景下检查自噬和心脏保护作用。本文还讨论了通过药理学诱导心脏自噬以增强心脏对缺血的耐受性的临床方法。
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