Pharmacopsychiatry. 2012 Nov;45(7):297-9. doi: 10.1055/s-0032-1306312. Epub 2012 Apr 3.
We report our experience with a 34-year-old patient with schizophrenia, paranoid subtype, who demonstrated an elevation of clozapine serum levels subsequent to pregabalin comedication used for the treatment of schizophrenic anxiety. This observation turned to be dose-dependent. Although the pharmacokinetic profile of pregabalin suggests an exclusive renal elimination, our report supports the presumption of a possible direct or indirect hepatic "effect" of pregabalin.
我们报告了一例 34 岁的偏执型精神分裂症患者的用药经验，在合用普瑞巴林治疗精神分裂症焦虑后，该患者的氯氮平血药浓度升高。这种观察结果是剂量依赖性的。尽管普瑞巴林的药代动力学特征表明其仅通过肾脏消除，但我们的报告支持了普瑞巴林可能存在直接或间接的肝脏“作用”的假设。
