Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Pediatrics. 2012 May;129(5):860-8. doi: 10.1542/peds.2011-1773. Epub 2012 Apr 2.
Coffee and other caffeinated beverages are commonly consumed in pregnancy. In adults, caffeine may interfere with sleep onset and have a dose-response effect similar to those seen during insomnia. In infancy, nighttime waking is a common event. With this study, we aimed to investigate if maternal caffeine consumption during pregnancy and lactation leads to frequent nocturnal awakening among infants at 3 months of age.
All children born in the city of Pelotas, Brazil, during 2004 were enrolled on a cohort study. Mothers were interviewed at delivery and after 3 months to obtain information on caffeine drinking consumption, sociodemographic, reproductive, and behavioral characteristics. Infant sleeping pattern in the previous 15 days was obtained from a subsample. Night waking was defined as an episode of infant arousal that woke the parents during nighttime. Multivariable analysis was performed by using Poisson regression.
The subsample included 885 of the 4231 infants born in 2004. All but 1 mother consumed caffeine in pregnancy. Nearly 20% were heavy consumers (≥300 mg/day) during pregnancy and 14.3% at 3 months postpartum. Prevalence of frequent nighttime awakeners (>3 episodes per night) was 13.8% (95% confidence interval: 11.5%-16.0%). The highest prevalence ratio was observed among breastfed infants from mothers consuming ≥300 mg/day during the whole pregnancy and in the postpartum period (1.65; 95% confidence interval: 0.86-3.17) but at a nonsignificant level.
Caffeine consumption during pregnancy and by nursing mothers seems not to have consequences on sleep of infants at the age of 3 months.
咖啡和其他含咖啡因的饮料在孕期内通常被摄入。在成年人中，咖啡因可能会干扰入睡，并产生类似于失眠期间所见的剂量反应效应。在婴儿期，夜间醒来是常见现象。通过这项研究，我们旨在调查母亲在孕期和哺乳期摄入咖啡因是否会导致 3 个月大的婴儿频繁夜间醒来。
所有在 2004 年出生于巴西佩洛塔斯市的儿童都参加了一项队列研究。母亲在分娩时和 3 个月后接受采访，以获取咖啡因饮用、社会人口统计学、生殖和行为特征的信息。从子样本中获取婴儿在过去 15 天的睡眠模式。夜间觉醒被定义为婴儿觉醒的事件，使父母在夜间醒来。采用泊松回归进行多变量分析。
子样本包括 2004 年出生的 4231 名婴儿中的 885 名。除 1 名母亲外，所有母亲在孕期均摄入咖啡因。近 20%的母亲在孕期是重度消费者（≥300mg/天），14.3%在产后 3 个月时是重度消费者。频繁夜间觉醒（>3 次/夜）的患病率为 13.8%（95%置信区间：11.5%-16.0%）。在整个孕期和产后期间从摄入≥300mg/天咖啡因的母乳喂养婴儿中观察到的最高患病率比最高（1.65；95%置信区间：0.86-3.17），但无统计学意义。
母亲在孕期和哺乳期摄入咖啡因似乎不会对 3 个月大婴儿的睡眠产生影响。
