de Medeiros Thamíris Santos, Bernardi Juliana Rombaldi, de Brito Mariana Lopes, Bosa Vera Lucia, Goldani Marcelo Zubaran, da Silva Clécio Homrich
Master of Sciences in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Center for the Study of Child and Adolescent Health, Hospital de Clínicas de Porto Alegre, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2nd floor, 2350, CEP 90035-903, Porto Alegre, RS, Brazil.
Matern Child Health J. 2017 Jun;21(6):1297-1307. doi: 10.1007/s10995-016-2230-7.
Objective To investigate the association between maternal caffeine intake during pregnancy and infant anthropometric measurements at age 3 and 6 months. Methods Longitudinal observational study of mother-child pairs stratified into five groups: diabetic women (DM), hypertensive women (HYP), smoking mothers (SMO), mothers of infants small for gestational age (SGA), and controls (CTL). Pairs were recruited from three public hospitals in Porto Alegre, Brazil, from 2011 to 2015, using a convenience sampling strategy. The Food Frequency Questionnaire (FFQ) was administered on postpartum day 7 to evaluate maternal caffeine intake during pregnancy. The anthropometric measurements of interest (weight, length, and skinfold thickness) were assessed at birth and at age 3 and 6 months. Linear regression was used to analyze the interaction between caffeine intake and skinfold thickness. Results Overall, 272 mother-child pairs were investigated (41 DM, 26 HYP, 68 SMO, 25 SGA, and 112 CTL). There were no differences in anthropometric measurements between infants born to mothers who had and had not consumed caffeine during pregnancy (P > 0.05). Children of mothers in the DM group had the highest adjusted average skinfold thicknesses at 3 months. An interaction between maternal caffeine intake during pregnancy and the sum of skinfolds at age 3 months was found in the DM and CTL groups (P < 0.05). However, significant differences were not observed at 6 months. Conclusions Maternal caffeine intake influenced infants skinfold thickness measurements at 3 months of age. This parameter was reduced in infants born to mothers with DM and increased in those born to healthy control mothers.
目的 探讨孕期母亲咖啡因摄入量与婴儿3个月和6个月时人体测量指标之间的关联。方法 对母婴对进行纵向观察性研究，分为五组：糖尿病女性（DM）、高血压女性（HYP）、吸烟母亲（SMO）、小于胎龄儿母亲（SGA）和对照组（CTL）。2011年至2015年期间，采用便利抽样策略从巴西阿雷格里港的三家公立医院招募母婴对。在产后第7天进行食物频率问卷调查（FFQ），以评估孕期母亲的咖啡因摄入量。在出生时以及3个月和6个月时评估感兴趣的人体测量指标（体重、身长和皮褶厚度）。使用线性回归分析咖啡因摄入量与皮褶厚度之间的相互作用。结果 总体上，共调查了272对母婴对（41对DM、26对HYP、68对SMO、25对SGA和112对CTL）。孕期摄入和未摄入咖啡因的母亲所生婴儿的人体测量指标没有差异（P>0.05）。DM组母亲的孩子在3个月时调整后的平均皮褶厚度最高。在DM组和CTL组中发现孕期母亲咖啡因摄入量与3个月时皮褶总和之间存在相互作用（P<0.05）。然而，在6个月时未观察到显著差异。结论 孕期母亲咖啡因摄入量影响婴儿3个月时的皮褶厚度测量值。糖尿病母亲所生婴儿的这一参数降低，而健康对照母亲所生婴儿的这一参数升高。
