Department of Neurology, Varaždin General Hospital, Varaždin, Croatia.
Neuroepidemiology. 2012;38(3):164-71. doi: 10.1159/000336114. Epub 2012 Mar 29.
In Central/Eastern European countries, cerebrovascular diseases are among the leading causes of mortality. We aimed to determine the incidence of first-ever stroke (FES) in the north-western part of Croatia.
A population-based prospective incidence study was conducted between July 1, 2007, and June 30, 2009. Cases were sought from multiple overlapping sources. Incidence rates by stroke type and gender were calculated.
A total of 1,487 events were recorded, 1,017 of which were FESs. European age-adjusted incidence rates (per 100,000 population) were: total FESs 223.6 [women/men rate ratio (w/m RR) = 0.65 (95% CI 0.57-0.73)]; ischemic stroke 162.4 (w/m RR = 0.65, 0.56-0.76); intracerebral hemorrhage 28.4 (w/m RR = 0.44, 0.30-0.63); subarachnoid hemorrhage 7.2 (w/m RR = 1.18, 0.55-2.54); unknown etiology 25.5 (w/m RR = 0.78, 0.54-1.14). Adjusted incidence rates of ischemic strokes by subtype were: cardioembolic 52.9 (w/m RR = 0.77, 0.59-0.99); large-artery atherosclerosis 14.4 (w/m RR = 0.22, 0.13-0.38); small-artery occlusion 24.5 (w/m RR = 0.53, 0.37-0.77) and 'other or uncertain causes' 70.6 (w/m RR = 0.77, 0.62-0.97). Thirty-day case-fatality rate was 23.5% overall and 17.1% for ischemic stroke.
The incidence of FES and 30-day mortality of patients with ischemic strokes in the studied population is higher than in Western European countries.
在中东欧国家，脑血管疾病是导致死亡的主要原因之一。我们旨在确定克罗地亚西北部首次发生中风（FES）的发病率。
在 2007 年 7 月 1 日至 2009 年 6 月 30 日期间进行了一项基于人群的前瞻性发病率研究。从多个重叠的来源寻找病例。按中风类型和性别计算发病率。
共记录了 1487 例事件，其中 1017 例为 FES。欧洲年龄调整后的发病率（每 100,000 人）为：总 FES 223.6 [女性/男性比率（w/m RR）= 0.65（95%CI 0.57-0.73）]；缺血性中风 162.4（w/m RR=0.65，0.56-0.76）；颅内出血 28.4（w/m RR=0.44，0.30-0.63）；蛛网膜下腔出血 7.2（w/m RR=1.18，0.55-2.54）；病因不明 25.5（w/m RR=0.78，0.54-1.14）。缺血性中风亚型的调整发病率为：心源性栓塞 52.9（w/m RR=0.77，0.59-0.99）；大动脉粥样硬化 14.4（w/m RR=0.22，0.13-0.38）；小动脉闭塞 24.5（w/m RR=0.53，0.37-0.77）和“其他或不确定原因”70.6（w/m RR=0.77，0.62-0.97）。总体 30 天病死率为 23.5%，缺血性中风患者为 17.1%。
在研究人群中，FES 的发病率和缺血性中风患者 30 天死亡率高于西欧国家。
