一项基于人群的前瞻性 24 个月研究：克罗地亚首次脑卒中的发病率和 30 天病死率。

A population-based prospective 24-month study of stroke: incidence and 30-day case-fatality rates of first-ever strokes in Croatia.

机构信息

Department of Neurology, Varaždin General Hospital, Varaždin, Croatia.

出版信息

Neuroepidemiology. 2012;38(3):164-71. doi: 10.1159/000336114. Epub 2012 Mar 29.

DOI:10.1159/000336114

PMID:22473420

Abstract

BACKGROUND

In Central/Eastern European countries, cerebrovascular diseases are among the leading causes of mortality. We aimed to determine the incidence of first-ever stroke (FES) in the north-western part of Croatia.

METHODS

A population-based prospective incidence study was conducted between July 1, 2007, and June 30, 2009. Cases were sought from multiple overlapping sources. Incidence rates by stroke type and gender were calculated.

RESULTS

A total of 1,487 events were recorded, 1,017 of which were FESs. European age-adjusted incidence rates (per 100,000 population) were: total FESs 223.6 [women/men rate ratio (w/m RR) = 0.65 (95% CI 0.57-0.73)]; ischemic stroke 162.4 (w/m RR = 0.65, 0.56-0.76); intracerebral hemorrhage 28.4 (w/m RR = 0.44, 0.30-0.63); subarachnoid hemorrhage 7.2 (w/m RR = 1.18, 0.55-2.54); unknown etiology 25.5 (w/m RR = 0.78, 0.54-1.14). Adjusted incidence rates of ischemic strokes by subtype were: cardioembolic 52.9 (w/m RR = 0.77, 0.59-0.99); large-artery atherosclerosis 14.4 (w/m RR = 0.22, 0.13-0.38); small-artery occlusion 24.5 (w/m RR = 0.53, 0.37-0.77) and 'other or uncertain causes' 70.6 (w/m RR = 0.77, 0.62-0.97). Thirty-day case-fatality rate was 23.5% overall and 17.1% for ischemic stroke.

CONCLUSIONS

The incidence of FES and 30-day mortality of patients with ischemic strokes in the studied population is higher than in Western European countries.

摘要

背景

在中东欧国家，脑血管疾病是导致死亡的主要原因之一。我们旨在确定克罗地亚西北部首次发生中风（FES）的发病率。

方法

在 2007 年 7 月 1 日至 2009 年 6 月 30 日期间进行了一项基于人群的前瞻性发病率研究。从多个重叠的来源寻找病例。按中风类型和性别计算发病率。

结果

共记录了 1487 例事件，其中 1017 例为 FES。欧洲年龄调整后的发病率（每 100,000 人）为：总 FES 223.6 [女性/男性比率（w/m RR）= 0.65（95%CI 0.57-0.73）]；缺血性中风 162.4（w/m RR=0.65，0.56-0.76）；颅内出血 28.4（w/m RR=0.44，0.30-0.63）；蛛网膜下腔出血 7.2（w/m RR=1.18，0.55-2.54）；病因不明 25.5（w/m RR=0.78，0.54-1.14）。缺血性中风亚型的调整发病率为：心源性栓塞 52.9（w/m RR=0.77，0.59-0.99）；大动脉粥样硬化 14.4（w/m RR=0.22，0.13-0.38）；小动脉闭塞 24.5（w/m RR=0.53，0.37-0.77）和“其他或不确定原因”70.6（w/m RR=0.77，0.62-0.97）。总体 30 天病死率为 23.5%，缺血性中风患者为 17.1%。