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光敏剂和万古霉素偶联新型多功能磁性颗粒作为光灭活剂，用于选择性杀灭致病菌。

Photosensitizer and vancomycin-conjugated novel multifunctional magnetic particles as photoinactivation agents for selective killing of pathogenic bacteria.

机构信息

Photon Applied Functional Molecule Research Laboratory, Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea.

出版信息

Chem Commun (Camb). 2012 May 14;48(38):4591-3. doi: 10.1039/c2cc17766h. Epub 2012 Apr 4.

DOI:10.1039/c2cc17766h
PMID:22473513
Abstract

Novel multifunctional magnetic particles (MMPs) conjugated with photosensitizer and vancomycin were fabricated by surface modification of Fe(3)O(4) particles. The capacities to target, capture and inactivate pathogenic bacteria and good biocompatibility suggest that the MMPs have great potentials as photodynamic inactivation agents for serious bacterial contamination.

摘要

新型多功能磁性粒子 (MMPs) 通过 Fe(3)O(4) 粒子的表面修饰与光敏剂和万古霉素偶联而成。靶向、捕获和灭活致病菌的能力以及良好的生物相容性表明，MMPs 作为严重细菌污染的光动力灭活剂具有巨大的潜力。

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