Ito S, Yoshimura H, Tamada T, Nishimura Y, Sato N, Ohishi H, Uchida H, Mizumoto K, Konishi Y
Department of Radiology and Oncoradiology, Nara Medical University.
Nihon Igaku Hoshasen Gakkai Zasshi. 1990 Sep 25;50(9):1108-18.
Efficacy of intraoperative electron beam radiotherapy (IOER) on N-nitrosobis (2-hydroxypropyl) amine (BHP) induced pancreatic carcinomas transplanted into the pancreas of the Syrian golden hamsters were studied and the following results were obtained. 1. Selective electron beam application to the carcinoma transplanted into the pancreas of hamsters was accomplished using an electron beam collimator. 2. Intra-pancreatic transplantability of BHP-induced serially transplantable subcutaneous pancreatic carcinomas was 100%. 3. Intra-pancreatic transplanted pancreatic carcinomas disappeared in 2 out of 19 hamsters (11%) by 10 Gy irradiation and 7 out of 15 (47%) by 20 Gy irradiation given 2 weeks after intra-pancreatic transplantation. 4. In contrast to the linear growth of tumor size in the non-irradiated group, the tumor size showed an electron dose-dependent reduction in the irradiated group. 5. Histologically, marked necrosis was noted in the irradiated group, and the intensity of necrosis differed between the 10 Gy and 20 Gy groups. 6. Direct invasion of tumor to the stomach, small intestine, large intestine, liver and abdominal wall was noted. Its incidence tended to decrease as the electron dose increased (5/19 or 26% for the control group, 4/19 or 21% for the 10 Gy group, and 1/17 or 6% for the 20 Gy group), although the difference was not statistically significant. 7. The incidences of liver and lymph node metastasis were not different between the non-irradiated and the irradiated groups. These results suggest that selective IOER on BHP-induced pancreatic carcinomas has an effectiveness to kill cancer cells in hamsters.
研究了术中电子束放射治疗（IOER）对N-亚硝基双（2-羟丙基）胺（BHP）诱导移植到叙利亚金仓鼠胰腺内的胰腺癌的疗效，并获得了以下结果。1. 使用电子束准直器对移植到仓鼠胰腺内的癌进行选择性电子束照射。2. BHP诱导的可连续移植的皮下胰腺癌在胰腺内的移植成功率为100%。3. 在胰腺内移植2周后，给予10 Gy照射，19只仓鼠中有2只（11%）胰腺内移植的胰腺癌消失；给予20 Gy照射，15只中有7只（47%）消失。4. 与未照射组肿瘤大小呈线性增长相反，照射组肿瘤大小呈电子剂量依赖性减小。5. 组织学上，照射组出现明显坏死，10 Gy和20 Gy组坏死程度不同。6. 观察到肿瘤直接侵犯胃、小肠、大肠、肝脏和腹壁。其发生率随电子剂量增加有下降趋势（对照组为5/19或26%，10 Gy组为4/19或21%，20 Gy组为1/17或6%），但差异无统计学意义。7. 未照射组和照射组的肝转移和淋巴结转移发生率无差异。这些结果表明，对BHP诱导的胰腺癌进行选择性IOER对杀死仓鼠体内的癌细胞有效。
