Department of Medicine, Case Western Reserve University-St. Vincent Charity Medical Center, Cleveland, OH 44115, USA.
Cleve Clin J Med. 2012 Apr;79(4):265-72. doi: 10.3949/ccjm.79a.11072.
The factor V Leiden mutation, the most common inherited cause of thrombophilia, causes a mild hypercoagulable state. We describe a 29-year-old man, heterozygous for factor V Leiden, who developed extensive pulmonary emboli with concomitant bilateral deep venous thrombosis, likely provoked by prolonged immobility during a car trip. We then review the diagnosis, therapy, screening, and prognosis of venous thromboembolism related to factor V Leiden.
凝血因子 V 莱顿突变是最常见的遗传性血栓形成倾向原因，可导致轻度高凝状态。我们描述了一位 29 岁的男性，因子 V 莱顿杂合子，在汽车旅行中长时间不动后，可能引发了广泛的肺栓塞伴双侧深静脉血栓形成。然后，我们回顾了与凝血因子 V 莱顿相关的静脉血栓栓塞症的诊断、治疗、筛查和预后。
