Oddo D, Etchart M, Thompson L
Department of Anatomic Pathology, Pontificia Universidad Católica de Chile, School of Medicine, Santiago.
Pathol Res Pract. 1990 Aug;186(4):514-7; discussion 518. doi: 10.1016/S0344-0338(11)80473-5.
A case of histoplasmosis duboisii in a 30 year-old engineer is presented. The diagnosis was made with the help of light microscopy, electron microscopy and cultures. Although diagnosed in Chile, the patient probably acquired the disease in the endemic African area, more precisely in the Ivory Coast. Differential diagnosis between Histoplasma capsulatum var. capsulatum and Histoplasma capsulatum var. duboisii is based primarily on the larger in-vivo yeast form size of the latter. Electron microscopy study, the first done on the duboisii variety of Histoplasma capsulatum in human material to our knowledge, was not essential for this purpose. Differential diagnosis between Histoplasma capsulatum var. duboisii and Blastomyces dermatitidis is based on morphological tissue changes and mycologic characteristics. Once more, a case of an "exotic" or geographically restricted disease is detected far from its endemic area, thanks to easier means of transportation. Earth is a shrinking planet.
本文介绍了一名30岁工程师患杜波伊斯组织胞浆菌病的病例。诊断借助光学显微镜、电子显微镜和培养完成。尽管该病例在智利确诊，但患者可能是在非洲流行地区，更确切地说是在象牙海岸感染的这种疾病。荚膜组织胞浆菌荚膜变种和杜波伊斯变种之间的鉴别诊断主要基于后者在体内酵母形式更大的尺寸。据我们所知，电子显微镜研究是首次对人体材料中的杜波伊斯变种荚膜组织胞浆菌进行的，然而这对于此目的并非必要。杜波伊斯变种荚膜组织胞浆菌与皮炎芽生菌之间的鉴别诊断基于形态学组织变化和真菌学特征。再一次，由于交通方式更加便捷，在远离其流行地区的地方发现了一例“外来”或地理上有局限的疾病。地球正在变成一个越来越小的星球。
